Antibiotics & Antivirals Library Chemical Structure : TP0586532
CAS No.: 2427584-96-9
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TP0586532 (TP 0586532)
Catalog No.: URK-V603聽聽Only Used For Lab.
TP0586532 (TP 0586532) is a novel non-hydroxamate inhibitor of UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) with IC50 of 0.101 uM, shows MIC values 2 mg/mL and 4 mg/mL for E. coli ATCC 25922 and K. pneumoniae ATCC 13883.
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Biological Activity
TP0586532 (TP 0586532) is a novel non-hydroxamate inhibitor of UDP-3-O-acyl-N--acetylglucosamine deacetylase (LpxC) with IC50 of 0.101 uM, shows MIC values 2 mg/mL and 4 mg/mL for E. coli ATCC 25922 and K. pneumoniae ATCC 13883; TP0586532 is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk. The MIC90 of TP0586532 against clinical isolates of carbapenem-resistant Klebsiella pneumoniae was 4 ug/mL. TP0586532 also showed an in vivo efficacy against murine systemic, urinary tract and lung infection models caused by meropenem- or ciprofloxacin-resistant strains. TP0586532 also reduces LPS release and IL-6 production both in vitro and in vivo.
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Physicochemical Properties
M.Wt560.534
FormulaC26H28N4O4
CAS No.2427584-96-9
StorageSolide Powder
-20 掳C 3years;
4掳C 2yearsIn Solvent
-80掳C 6 Months
-20掳C 1 Months
Solubility聽
Chemical Name聽
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References
1. Ushiyama F, et al. Bioorg Med Chem. 2021 Jan 15;30:115964.
2. Fujita K, et al. J Antibiot (Tokyo). 2022 Feb;75(2):98-107.
3. Fujita K, et al. J Antibiot (Tokyo). 2022 Mar;75(3):136-145.
URK-V603_COA
URK-V603_SDS
URK-V603_TDS
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聽Antibiotics & Antivirals Library
website:http://www.ureiko-chem.com/inhibitors-agonists/antibiotics-antivirals-library/